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Sci Rep ; 10(1): 21040, 2020 12 03.
Article in English | MEDLINE | ID: covidwho-1493184

ABSTRACT

We apply tools from functional data analysis to model cumulative trajectories of COVID-19 cases across countries, establishing a framework for quantifying and comparing cases and deaths across countries longitudinally. It emerges that a country's trajectory during an initial first month "priming period" largely determines how the situation unfolds subsequently. We also propose a method for forecasting case counts, which takes advantage of the common, latent information in the entire sample of curves, instead of just the history of a single country. Our framework facilitates to quantify the effects of demographic covariates and social mobility on doubling rates and case fatality rates through a time-varying regression model. Decreased workplace mobility is associated with lower doubling rates with a roughly 2 week delay, and case fatality rates exhibit a positive feedback pattern.


Subject(s)
COVID-19/epidemiology , Pandemics/statistics & numerical data , Forecasting/methods , Humans , Models, Statistical , Risk Factors
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